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Their joint crusade, stated repeatedly in editorials for the journal and since expanded in books and dozens of articles in the lay press, is against for-profit medicine, especially its ancillary profit centers of commercial insurance and drug manufacture — in Dr. Relman’s words, “the people who are making a zillion bucks out of the commercial exploitation of medicine.”Some have dismissed the pair as medical Don Quixotes, comically deluded figures tilting at benign features of the landscape. Others consider them first responders in what has become a battle for the soul of American medicine.They met almost 50 years ago. He was a star of the academic medical scene in Boston, a Brooklyn boy who wanted to be a philosopher but had to make a living. She was born in Tennessee and raised in Virginia, worked in microbiology labs through college and after, then landed in medical school at Boston University, an older student and one of 8 women in a class of 80.