If you could get close to the speed of light, the time dilation would allow you to travel a lot farther than your normal lifespan in light years (but would take an absurd amount of energy). Alternatively, there could be a large self contained space civilization that would make the journey over multiple generations. Or, medical technology would advance to the point that all body parts could be replaced with young clone tissue, and lifespans would be limitless.
Wormholes are a nice plot device, but unless there was a reasonable way to produce/stabilize one, it'll never be any more than that.