My pick: the next Democratic presidential candidate will be either a not-Hillary woman, a Hispanic from Florida or anyone-but-Biden.
The Republicans will pick Chris Christie or perhaps Rock Santorum, lose, and be even moar butthurt. Presuming Obama doesn't drive everybody into double-dip recession with the stupid self-imposed fiscal cliff thing, unemployment will trend down until full employment and the next election will be fought on morning in America.
Them's my picks.