I just ignore it, Nick. Love and tolerate, that's all I do :3 If I show the show to a friend and they don't get into it, I don't badger them about it, and I limit my pony references around them to keep the annoyance to them down. I don't hold it against anypony. They're entitled to their opinions, even if they happen to be semi-hostile about it. I treat them like I would Trixie, Gilda, or Blueblood. Smile, nod, be pleasant, and don't let them bother you. I've rather taken up the policy 'what would Celestia do?'