He just did another
AMA on Reddit. It went as expected. One of the other poignant parts of the AMA besides the doctor breaking it down Barney-style to Shkreli as to why a 5000% price inflation of a drug is a bad thing for everybody was when someone called him a "Fu** boy". Shkreli replied, "No U", but I can't help to think that got under his skin a little.
But to Shkreli, it's all fun and games. He's a millionaire, he is in charge of a small company, and probably most important to him, he's famous. Even if it's infamy and notoriety, he's famous, and that makes him, in his mind, super successful.
Worse, he also thinks of himself as a successful IRL troll. He gets a kick from irritating people not realizing that if he doesn't wise up from his antics, he's going to become a modern day parable as to why trolling IRL is a stupid idea.
Shkreli seems to have trouble in social interaction in general. Whether it's from a misdiagnosed/undiagnosed problem, him just being a painfully socially awkward and inept person, or him relishing in being an A-hole because he has a terrible personality, at the end of the day I can't imagine him having proud parents/guardians that he talks to.
At the rate he's going, Shkreli is going to die alone because I can't imagine some good woman in her right mind dating this guy. If he does manage to snag someone, I can't imagine things ending well for him or his date.